Phosphatidic Acid Signals via the Hippo Pathway

The hippo pathway.

The Hippo pathway (Fig. 1), also known as the SalvadorWarts-Hippo pathway, regulates tissue growth in a wide variety of organisms (Harvey and Tapon 2007; Grusche et al. 2010; Oh and Irvine 2010; Pan 2010; Halder and Johnson 2011; Zhao et al. 2011). Many components of the pathway were identified as a result of mutations in the fruit fly Drosophila melanogaster that resulted in tissue overgrowth ...

Okadaic Acid: A Tool to Study the Hippo Pathway

Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor. MST1 and MST2 work as core kinases of the Hippo pathway and their activities depend on the autophosphorylation, which is negatively regulated by protein phosphatase 2A (PP2A). Okadaic acid has been frequ...

RASSF1A downregulates AREG by activation of Hippo pathway RASSF1A-mediated regulation of amphiregulin via the Hippo pathway in hepatocellular carcinoma

Ras association domain family 1 isoform A (RASSF1A) is a tumor suppressor and the methylation thereof is known to be involved in many human cancers including hepatocellular carcinoma (HCC). RASSF1A has been shown to suppress tumors via activation of components of the Hippo tumor suppressor pathway, including mammalian STE20-like kinase (MST). Amphiregulin (AREG), a target gene for Yes-associate...

The Hippo signaling pathway interactome.

The Hippo pathway controls metazoan organ growth by regulating cell proliferation and apoptosis. Many components have been identified, but our knowledge of the composition and structure of this pathway is still incomplete. Using existing pathway components as baits, we generated by mass spectrometry a high-confidence Drosophila Hippo protein-protein interaction network (Hippo-PPIN) consisting o...

SnapShot: The Hippo Signaling Pathway